This study aims to present an efficient methodology for building a global supply chain in cross-border e-commerce (CBEC), which is growing rapidly at an average annual rate of about 30% based on information and communication technology (ICT), the latest example of the 4th industrial revolution. In order to conduct a systematic study, based on the framework for conducting the study, we first derived three detailed options to consider when building a global supply chain for CBEC: a global supply chain model option, a global supply chain operation option, and a global supply chain entity option through prior research on CBEC and interviews with experts. Accordingly, based on representative case studies and expert interviews for each detailed option, an evaluation system was established to select alternatives for each detailed option of CBEC global supply chain construction. The main theoretical implications of this study are the expansion of the study to six CBEC global supply chain construction models, and the systematization of the research methodology for CBEC global supply chain construction plans, which takes into account external environmental logistics uncertainties. The main practical implications are the presentation of an evaluation system that can support CBEC participants in making rational decisions in order to improve logistics competitiveness in the CBEC global supply chain, along with case studies of major representative companies. This study aims to lay the foundation for improving logistics competitiveness in the CBEC global supply chain through rational decision-making.